Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis

Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis

Hepatocellular carcinoma (HCC) is difficult to treat, and is the second leading cause of cancer-related death worldwide. This study aimed to examine whether combination of wogonin and artesunate exhibits synergistic anti-HCC effect. Our data show that the combination treatment exhibits synergistic e...

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Bibliographic Details
Main Authors: Minting Chen, Hsin Ling Wu, Tsz Sin Wong, Baisen Chen, Rui-Hong Gong, Hoi Leong Xavier Wong, Haitao Xiao, Zhaoxiang Bian, Hiu Yee Kwan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
artesunate
wogonin
hepatocellular carcinoma
GADD45a
GADD45
tumor necrosis factor-α
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.657080/full

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