Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model

Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model

Augmented renal clearance (ARC) observed in the critically ill pediatric population has received an increased attention over the last years due to its major impact on the disposition and pharmacokinetics of mainly renally excreted drugs. Apart from an important inflammatory trigger, fluid administra...

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Bibliographic Details
Main Authors: Laura Dhondt, Siska Croubels, Peter De Paepe, Klara Goethals, Pieter De Cock, Mathias Devreese
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
augmented renal clearance
fluid therapy
large animal model
piglet
iohexol
para-aminohippuric acid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.607101/full

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