Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy

Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy

Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with...

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Bibliographic Details
Main Authors: Berislav Bošnjak, Ivan Odak, Christiane Ritter, Klaus Stahl, Theresa Graalmann, Lars Steinbrück, Rainer Blasczyk, Christine S. Falk, Thomas F. Schulz, Hans Heinrich Wedemeyer, Markus Cornberg, Arnold Ganser, Reinhold Förster, Christian Koenecke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
convalescent plasma (CP)
COVID – 19
SARS – CoV – 2
NK cell
T cell
CD19 CAR-T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.721738/full

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