Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.721738/full |
| id |
doaj-6ca321676619473c9571183ea2adfb2b |
|---|---|
| record_format |
Article |
| spelling |
doaj-6ca321676619473c9571183ea2adfb2b2021-08-12T07:44:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-08-011210.3389/fimmu.2021.721738721738Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell TherapyBerislav Bošnjak0Ivan Odak1Christiane Ritter2Klaus Stahl3Theresa Graalmann4Theresa Graalmann5Lars Steinbrück6Rainer Blasczyk7Christine S. Falk8Christine S. Falk9Thomas F. Schulz10Thomas F. Schulz11Thomas F. Schulz12Hans Heinrich Wedemeyer13Hans Heinrich Wedemeyer14Hans Heinrich Wedemeyer15Markus Cornberg16Markus Cornberg17Markus Cornberg18Arnold Ganser19Reinhold Förster20Reinhold Förster21Christian Koenecke22Christian Koenecke23Christian Koenecke24Institute of Immunology, Hannover Medical School, Hannover, GermanyInstitute of Immunology, Hannover Medical School, Hannover, GermanyInstitute of Immunology, Hannover Medical School, Hannover, GermanyDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, GermanyDepartment of Rheumatology and Clinical Immunology, Hannover Medical School, Hannover, GermanyTWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, GermanyInstitute of Virology, Hannover Medical School, Hannover, GermanyInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, GermanyInstitute of Transplantation Immunology, Hannover Medical School, Hannover, Germany German Center for Infection Research (DZIF), Partner Site, Hannover-Braunschweig, GermanyInstitute of Virology, Hannover Medical School, Hannover, Germany German Center for Infection Research (DZIF), Partner Site, Hannover-Braunschweig, GermanyCluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, GermanyDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, GermanyCluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany0Centre for Individualized Infection Medicine (CiiM) , Hannover, GermanyDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, GermanyCluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany0Centre for Individualized Infection Medicine (CiiM) , Hannover, Germany1Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, GermanyInstitute of Immunology, Hannover Medical School, Hannover, GermanyCluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, GermanyInstitute of Immunology, Hannover Medical School, Hannover, Germany0Centre for Individualized Infection Medicine (CiiM) , Hannover, Germany1Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, GermanyHere, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.https://www.frontiersin.org/articles/10.3389/fimmu.2021.721738/fullconvalescent plasma (CP)COVID – 19SARS – CoV – 2NK cellT cellCD19 CAR-T cell |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Berislav Bošnjak Ivan Odak Christiane Ritter Klaus Stahl Theresa Graalmann Theresa Graalmann Lars Steinbrück Rainer Blasczyk Christine S. Falk Christine S. Falk Thomas F. Schulz Thomas F. Schulz Thomas F. Schulz Hans Heinrich Wedemeyer Hans Heinrich Wedemeyer Hans Heinrich Wedemeyer Markus Cornberg Markus Cornberg Markus Cornberg Arnold Ganser Reinhold Förster Reinhold Förster Christian Koenecke Christian Koenecke Christian Koenecke |
| spellingShingle |
Berislav Bošnjak Ivan Odak Christiane Ritter Klaus Stahl Theresa Graalmann Theresa Graalmann Lars Steinbrück Rainer Blasczyk Christine S. Falk Christine S. Falk Thomas F. Schulz Thomas F. Schulz Thomas F. Schulz Hans Heinrich Wedemeyer Hans Heinrich Wedemeyer Hans Heinrich Wedemeyer Markus Cornberg Markus Cornberg Markus Cornberg Arnold Ganser Reinhold Förster Reinhold Förster Christian Koenecke Christian Koenecke Christian Koenecke Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy Frontiers in Immunology convalescent plasma (CP) COVID – 19 SARS – CoV – 2 NK cell T cell CD19 CAR-T cell |
| author_facet |
Berislav Bošnjak Ivan Odak Christiane Ritter Klaus Stahl Theresa Graalmann Theresa Graalmann Lars Steinbrück Rainer Blasczyk Christine S. Falk Christine S. Falk Thomas F. Schulz Thomas F. Schulz Thomas F. Schulz Hans Heinrich Wedemeyer Hans Heinrich Wedemeyer Hans Heinrich Wedemeyer Markus Cornberg Markus Cornberg Markus Cornberg Arnold Ganser Reinhold Förster Reinhold Förster Christian Koenecke Christian Koenecke Christian Koenecke |
| author_sort |
Berislav Bošnjak |
| title |
Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
| title_short |
Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
| title_full |
Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
| title_fullStr |
Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
| title_full_unstemmed |
Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
| title_sort |
case report: convalescent plasma therapy induced anti-sars-cov-2 t cell expansion, nk cell maturation and virus clearance in a b cell deficient patient after cd19 car t cell therapy |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2021-08-01 |
| description |
Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients. |
| topic |
convalescent plasma (CP) COVID – 19 SARS – CoV – 2 NK cell T cell CD19 CAR-T cell |
| url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.721738/full |
| work_keys_str_mv |
AT berislavbosnjak casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT ivanodak casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT christianeritter casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT klausstahl casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT theresagraalmann casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT theresagraalmann casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT larssteinbruck casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT rainerblasczyk casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT christinesfalk casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT christinesfalk casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT thomasfschulz casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT thomasfschulz casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT thomasfschulz casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT hansheinrichwedemeyer casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT hansheinrichwedemeyer casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT hansheinrichwedemeyer casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT markuscornberg casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT markuscornberg casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT markuscornberg casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT arnoldganser casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT reinholdforster casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT reinholdforster casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT christiankoenecke casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT christiankoenecke casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy AT christiankoenecke casereportconvalescentplasmatherapyinducedantisarscov2tcellexpansionnkcellmaturationandvirusclearanceinabcelldeficientpatientaftercd19cartcelltherapy |
| _version_ |
1721209682442321920 |