egc Superantigens Impair Monocytes/Macrophages Inducing Cell Death and Inefficient Activation

egc Superantigens Impair Monocytes/Macrophages Inducing Cell Death and Inefficient Activation

Bacterial superantigens (SAgs) are enterotoxins that bind to MHC-II and TCR molecules, activating as much as 20% of the T cell population and promoting a cytokine storm which enhances susceptibility to endotoxic shock, causing immunosuppression, and hindering the immune response against bacterial in...

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Bibliographic Details
Main Authors: Sofia Noli Truant, Mauricio C. De Marzi, María B. Sarratea, María B. Antonoglou, Ana P. Meo, Laura V. Iannantuono López, María J. Fernández Lynch, Marcos Todone, Emilio L. Malchiodi, Marisa M. Fernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
superantigens
monocytes
innate immune response
gp130
MHC-II
THP-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03008/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03008/full

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