On the quantitative importance of omega-oxidation of fatty acids.
The relative importance of omega-oxidation of fatty acids in livers of starved rats was studied by determination of the ratio between 14C at C1 and at C2, C3, C4 in acetoacetate formed from [16-14C]palmitic acid in vivo and in vitro and from [10(-14)C]decanoic acid in vitro. The results are consiste...
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| Format: | Article |
| Language: | English |
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Elsevier
1978-07-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520412908 |
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doaj-6c9cf838962f4c24ac79c08d180075562021-04-24T05:53:28ZengElsevierJournal of Lipid Research0022-22751978-07-01195585590On the quantitative importance of omega-oxidation of fatty acids.I BjörkhemThe relative importance of omega-oxidation of fatty acids in livers of starved rats was studied by determination of the ratio between 14C at C1 and at C2, C3, C4 in acetoacetate formed from [16-14C]palmitic acid in vivo and in vitro and from [10(-14)C]decanoic acid in vitro. The results are consistent with the possibility that at least a small fraction of the fatty acids may be subject to primary omega-oxidation prior to beta-oxidation in the ketotic state. The maximal figure for this pathway was calculated to be of the magnitude 5–10%. The metabolic consequences of a pathway involving primary omega-oxidation of fatty acids are discussed.http://www.sciencedirect.com/science/article/pii/S0022227520412908 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
I Björkhem |
| spellingShingle |
I Björkhem On the quantitative importance of omega-oxidation of fatty acids. Journal of Lipid Research |
| author_facet |
I Björkhem |
| author_sort |
I Björkhem |
| title |
On the quantitative importance of omega-oxidation of fatty acids. |
| title_short |
On the quantitative importance of omega-oxidation of fatty acids. |
| title_full |
On the quantitative importance of omega-oxidation of fatty acids. |
| title_fullStr |
On the quantitative importance of omega-oxidation of fatty acids. |
| title_full_unstemmed |
On the quantitative importance of omega-oxidation of fatty acids. |
| title_sort |
on the quantitative importance of omega-oxidation of fatty acids. |
| publisher |
Elsevier |
| series |
Journal of Lipid Research |
| issn |
0022-2275 |
| publishDate |
1978-07-01 |
| description |
The relative importance of omega-oxidation of fatty acids in livers of starved rats was studied by determination of the ratio between 14C at C1 and at C2, C3, C4 in acetoacetate formed from [16-14C]palmitic acid in vivo and in vitro and from [10(-14)C]decanoic acid in vitro. The results are consistent with the possibility that at least a small fraction of the fatty acids may be subject to primary omega-oxidation prior to beta-oxidation in the ketotic state. The maximal figure for this pathway was calculated to be of the magnitude 5–10%. The metabolic consequences of a pathway involving primary omega-oxidation of fatty acids are discussed. |
| url |
http://www.sciencedirect.com/science/article/pii/S0022227520412908 |
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AT ibjorkhem onthequantitativeimportanceofomegaoxidationoffattyacids |
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