An Inhibitory Role of Osthole in Rat MSCs Osteogenic Differentiation and Proliferation via Wnt/β-Catenin and Erk1/2-MAPK Pathways

An Inhibitory Role of Osthole in Rat MSCs Osteogenic Differentiation and Proliferation via Wnt/β-Catenin and Erk1/2-MAPK Pathways

Background/Aims: Bone marrow-derived mesenchymal stem cells (MSCs) are responsible for new bone formation during adulthood. Accumulating evidences showed that Osthole promotes the osteogenic differentiation in primary osteoblasts. The aim of this study was to investigate whether Osthole exhibits a p...

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Bibliographic Details
Main Authors: Hongyang Hu, Min Chen, Guangzu Dai, Guoqing Du, Xuezong Wang, Jie He, Yongfang Zhao, Dapeng Han, Yuelong Cao, Yuxin Zheng, Daofang Ding
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Osthole
Mesenchymal stem cells
Proliferation
Osteogenic differentiation
Signaling pathway
Online Access:http://www.karger.com/Article/FullText/445590

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