Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast.

Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast.

Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington's disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing endogenous QN-rich proteins in the aggregated (p...

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Bibliographic Details
Main Authors: He Gong, Nina V Romanova, Kim D Allen, Pavithra Chandramowlishwaran, Kavita Gokhale, Gary P Newnam, Piotr Mieczkowski, Michael Y Sherman, Yury O Chernoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3334884?pdf=render

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