Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets.

Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets.

ColoPulse tablets are an innovative development in the field of oral dosage forms characterized by a distal ileum and colon-specific release. Previous studies in humans showed release in the ileo-colonic region, but the relationship between gastrointestinal pH and release was not experimentally prov...

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Bibliographic Details
Main Authors: Jacoba M Maurer, Reinout C A Schellekens, Hèlen M van Rieke, Christoph Wanke, Ventzeslav Iordanov, Frans Stellaard, Klaus D Wutzke, Gerard Dijkstra, Margot van der Zee, Herman J Woerdenbag, Henderik W Frijlink, Jos G W Kosterink
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4503763?pdf=render

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