2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation

2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation

The cysteine protease falcipain-2 (FP-2) of Plasmodium falciparum is a principal cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites, making it become an attractive target enzyme for developing anti-malarial drugs. In this study, a series of novel small molecu...

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Bibliographic Details
Main Authors: Hualiang Jiang, Jian Li, Honglin Li, Jin Huang, Weiqiang Lu, Ruoqun Ma, Jie Liu, Jin Zhu, Tong Chen
Format: Article
Language:English
Published: MDPI AG 2009-02-01
Series:Molecules
Subjects:
2-(3
4-Dihydro-4-oxothieno[2
3-d]pyrimidin-2-ylthio)acetamide derivatives
Falcipain-2 inhibitor
Malaria
SAR
Online Access:http://www.mdpi.com/1420-3049/14/2/785/

Internet

http://www.mdpi.com/1420-3049/14/2/785/

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