Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol.

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol.

A hallmark of Alzheimer's disease (AD) is the accumulation of extracellular amyloid-β (Aβ) plaques in the brains of patients. N-terminally truncated pyroglutamate-modified Aβ (pEAβ) has been described as a major compound of Aβ species in senile plaques. pEAβ is more resistant to degradation, sh...

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Bibliographic Details
Main Authors: Christina Dammers, Lothar Gremer, Kerstin Reiß, Antonia N Klein, Philipp Neudecker, Rudolf Hartmann, Na Sun, Hans-Ulrich Demuth, Melanie Schwarten, Dieter Willbold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4658145?pdf=render

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