Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds

Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds

Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were...

Full description

Bibliographic Details
Main Authors: Krisztina Takács-Novák, József Kökösi, Szabolcs Béni, Melinda Pálfi, Bálint Sinkó
Format: Article
Language:English
Published: MDPI AG 2010-02-01
Series:Molecules
Subjects:
ceramide-analogues
tartradiamides
transdermal penetration
apoptosis
Online Access:http://www.mdpi.com/1420-3049/15/2/824/
id doaj-6c51f42257c74849a167f4a816580012
record_format Article
spelling doaj-6c51f42257c74849a167f4a8165800122020-11-24T23:33:05ZengMDPI AGMolecules1420-30492010-02-0115282483310.3390/molecules15020824Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like CompoundsKrisztina Takács-NovákJózsef KökösiSzabolcs BéniMelinda PálfiBálint SinkóCeramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated. http://www.mdpi.com/1420-3049/15/2/824/ceramide-analoguestartradiamidestransdermal penetrationapoptosis
collection DOAJ
language English
format Article
sources DOAJ
author Krisztina Takács-Novák
József Kökösi
Szabolcs Béni
Melinda Pálfi
Bálint Sinkó
spellingShingle Krisztina Takács-Novák
József Kökösi
Szabolcs Béni
Melinda Pálfi
Bálint Sinkó
Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
Molecules
ceramide-analogues
tartradiamides
transdermal penetration
apoptosis
author_facet Krisztina Takács-Novák
József Kökösi
Szabolcs Béni
Melinda Pálfi
Bálint Sinkó
author_sort Krisztina Takács-Novák
title Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_short Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_full Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_fullStr Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_full_unstemmed Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds
title_sort synthesis and characterization of long-chain tartaric acid diamides as novel ceramide-like compounds
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2010-02-01
description Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated.
topic ceramide-analogues
tartradiamides
transdermal penetration
apoptosis
url http://www.mdpi.com/1420-3049/15/2/824/
work_keys_str_mv AT krisztinatakacsnovak synthesisandcharacterizationoflongchaintartaricaciddiamidesasnovelceramidelikecompounds
AT jozsefkokosi synthesisandcharacterizationoflongchaintartaricaciddiamidesasnovelceramidelikecompounds
AT szabolcsbeni synthesisandcharacterizationoflongchaintartaricaciddiamidesasnovelceramidelikecompounds
AT melindapalfi synthesisandcharacterizationoflongchaintartaricaciddiamidesasnovelceramidelikecompounds
AT balintsinko synthesisandcharacterizationoflongchaintartaricaciddiamidesasnovelceramidelikecompounds
_version_ 1725532135882752000

Similar Items