Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds

Synthesis and Characterization of Long-Chain Tartaric Acid Diamides as Novel Ceramide-Like Compounds

Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were...

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Bibliographic Details
Main Authors: Krisztina Takács-Novák, József Kökösi, Szabolcs Béni, Melinda Pálfi, Bálint Sinkó
Format: Article
Language:English
Published: MDPI AG 2010-02-01
Series:Molecules
Subjects:
ceramide-analogues
tartradiamides
transdermal penetration
apoptosis
Online Access:http://www.mdpi.com/1420-3049/15/2/824/
Description
Summary:Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated.
ISSN:1420-3049

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