The use of HEPES-buffer in the production of gallium-68 radiopharmaceuticals – time to reconsider strict pharmacopoeial limits?

The use of HEPES-buffer in the production of gallium-68 radiopharmaceuticals – time to reconsider strict pharmacopoeial limits?

Abstract HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) is a buffer that is used in the radiolabelling of gallium-68 compounds. The beneficial effects of HEPES on molar activity in bioconjugates have been well described. Current strict regulations on the HEPES content in radiopharmaceut...

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Bibliographic Details
Main Authors: Jannie le Roux, Janke Kleynhans, Sietske Rubow
Format: Article
Language:English
Published: SpringerOpen 2021-04-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
HEPES
Gallium-68
Radiopharmaceuticals
Limits
Toxicity
Human use
Online Access:https://doi.org/10.1186/s41181-021-00129-w

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