Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in disease and infection (e.g., autoimmunity, can...
Main Authors: | Enkelejda Miho, Alexander Yermanos, Cédric R. Weber, Christoph T. Berger, Sai T. Reddy, Victor Greiff |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-02-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00224/full |
Similar Items
-
Prospective Artificial Intelligence to Dissect the Dengue Immune Response and Discover Therapeutics
by: Eriberto N. Natali, et al.
Published: (2021-06-01) -
Large-scale network analysis reveals the sequence space architecture of antibody repertoires
by: Enkelejda Miho, et al.
Published: (2019-03-01) -
Tracing Antibody Repertoire Evolution by Systems Phylogeny
by: Alexander Dimitri Yermanos, et al.
Published: (2018-10-01) -
Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development
by: Victor Greiff, et al.
Published: (2017-05-01) -
IgM Antibody Repertoire Fingerprints in Mice Are Personalized but Robust to Viral Infection Status
by: Alexander Yermanos, et al.
Published: (2020-05-01)