Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis
Engineering dynamic control can improve microbial production of target chemicals. Here, the authors design a sensor-regulator and RNAi based bifunctional dynamic control network that can simultaneously and independently turn up and down cellular metabolism for engineered muconic acid production in E...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05466-0 |
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doaj-6c41fd6cf0b14e55acf1811ff0d399e92021-05-11T10:03:49ZengNature Publishing GroupNature Communications2041-17232018-08-019111010.1038/s41467-018-05466-0Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesisYaping Yang0Yuheng Lin1Jian Wang2Yifei Wu3Ruihua Zhang4Mengyin Cheng5Xiaolin Shen6Jia Wang7Zhenya Chen8Chenyi Li9Qipeng Yuan10Yajun Yan11School of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of GeorgiaSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of GeorgiaSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of GeorgiaBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical TechnologySchool of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of GeorgiaSchool of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of GeorgiaBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical TechnologyBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical TechnologyBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical TechnologySchool of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of GeorgiaBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical TechnologySchool of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of GeorgiaEngineering dynamic control can improve microbial production of target chemicals. Here, the authors design a sensor-regulator and RNAi based bifunctional dynamic control network that can simultaneously and independently turn up and down cellular metabolism for engineered muconic acid production in E. coli.https://doi.org/10.1038/s41467-018-05466-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yaping Yang Yuheng Lin Jian Wang Yifei Wu Ruihua Zhang Mengyin Cheng Xiaolin Shen Jia Wang Zhenya Chen Chenyi Li Qipeng Yuan Yajun Yan |
| spellingShingle |
Yaping Yang Yuheng Lin Jian Wang Yifei Wu Ruihua Zhang Mengyin Cheng Xiaolin Shen Jia Wang Zhenya Chen Chenyi Li Qipeng Yuan Yajun Yan Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis Nature Communications |
| author_facet |
Yaping Yang Yuheng Lin Jian Wang Yifei Wu Ruihua Zhang Mengyin Cheng Xiaolin Shen Jia Wang Zhenya Chen Chenyi Li Qipeng Yuan Yajun Yan |
| author_sort |
Yaping Yang |
| title |
Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis |
| title_short |
Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis |
| title_full |
Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis |
| title_fullStr |
Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis |
| title_full_unstemmed |
Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis |
| title_sort |
sensor-regulator and rnai based bifunctional dynamic control network for engineered microbial synthesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
Engineering dynamic control can improve microbial production of target chemicals. Here, the authors design a sensor-regulator and RNAi based bifunctional dynamic control network that can simultaneously and independently turn up and down cellular metabolism for engineered muconic acid production in E. coli. |
| url |
https://doi.org/10.1038/s41467-018-05466-0 |
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