Sensor-regulator and RNAi based bifunctional dynamic control network for engineered microbial synthesis

Engineering dynamic control can improve microbial production of target chemicals. Here, the authors design a sensor-regulator and RNAi based bifunctional dynamic control network that can simultaneously and independently turn up and down cellular metabolism for engineered muconic acid production in E...

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Bibliographic Details
Main Authors: Yaping Yang, Yuheng Lin, Jian Wang, Yifei Wu, Ruihua Zhang, Mengyin Cheng, Xiaolin Shen, Jia Wang, Zhenya Chen, Chenyi Li, Qipeng Yuan, Yajun Yan
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05466-0
Description
Summary:Engineering dynamic control can improve microbial production of target chemicals. Here, the authors design a sensor-regulator and RNAi based bifunctional dynamic control network that can simultaneously and independently turn up and down cellular metabolism for engineered muconic acid production in E. coli.
ISSN:2041-1723