Systemic ALK-positive anaplastic large cell lymphoma involving implant site: a fortuitous association

• Main Authors: Mayur Parkhi, Charanpreet Singh, Rajender Kumar, Pankaj Malhotra, Amanjit Bal
• Format: Article
• Language: English
• Published: University of São Paulo 2021-08-01
• Series: Autopsy and Case Reports
• Subjects: Femoral Fractures; Prostheses and Implants; Lymphoma; Large-Cell; Anaplastic; Anaplastic Lymphoma Kinase
• Online Access: https://www.revistas.usp.br/autopsy/article/view/190028

Anaplastic lymphoma kinase (ALK) positive, anaplastic large cell lymphoma involving the non-mammary implant is an extremely rare presentation. Irrespective of the type or site, the implant-associated primary ALCL is morphologically and immunophenotypically similar to ALK-negative ALCLs. Herein, we present the case of a 42-year-old male who developed a lytic lesion after an implant for a right femur fracture. The lytic lesion biopsy revealed anaplastic large cell lymphoma with ALK protein expression. Imaging findings showed the widespread dissemination of disease all over the body, entrapping the implant too. ALCL involving the bone implant is a very unusual and rare presentation that needs to be documented.