BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes

BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes

Type 1 diabetes (T1D) results from the progressive loss of pancreatic beta cells as a result of autoimmune destruction. We recently reported that during the natural history of T1D in humans and the female nonobese diabetic (NOD) mouse model, beta cells acquire a senescence-associated secretory pheno...

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Bibliographic Details
Main Authors: Peter J. Thompson, Ajit Shah, Hara Apostolopolou, Anil Bhushan
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
senescence and sasp
beta cells
type 1 diabetes
bet proteins
Online Access:https://www.mdpi.com/1422-0067/20/19/4776

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