Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

Reactive oxygen species in the tumour microenvironment can have an immunosuppressive effect. Here, the authors devise a nanoparticle that anchors to the extracellular matrix within tumours and scavenges reactive oxygen species, resulting in an enhanced immune response within the tumour.

Bibliographic Details
Main Authors: Hongzhang Deng, Weijing Yang, Zijian Zhou, Rui Tian, Lisen Lin, Ying Ma, Jibin Song, Xiaoyuan Chen
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18745-6
Description
Summary:Reactive oxygen species in the tumour microenvironment can have an immunosuppressive effect. Here, the authors devise a nanoparticle that anchors to the extracellular matrix within tumours and scavenges reactive oxygen species, resulting in an enhanced immune response within the tumour.
ISSN:2041-1723

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