Quantifying Gene Essentiality Based on the Context of Cellular Components

Quantifying Gene Essentiality Based on the Context of Cellular Components

Different genes have their protein products localized in various subcellular compartments. The diversity in protein localization may serve as a gene characteristic, revealing gene essentiality from a subcellular perspective. To measure this diversity, we introduced a Subcellular Diversity Index (SDI...

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Bibliographic Details
Main Authors: Kaiwen Jia, Yuan Zhou, Qinghua Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Genetics
Subjects:
cellular components
localization diversity
gene characteristic
gene essentiality
drug target
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01342/full

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