Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease

Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease

Chronic exposure to high circulating levels of glucocorticoids (GCs) may be a key risk factor for Alzheimer's Disease (AD) development and progression. In addition, hyper-activation of glucocorticoid receptors (GRs) induces brain alterations comparable to those produced by AD. In transgenic mou...

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Bibliographic Details
Main Authors: Matteo Pedrazzoli, Morris Losurdo, Giovanna Paolone, Manuela Medelin, Lejdi Jaupaj, Barbara Cisterna, Anna Slanzi, Manuela Malatesta, Silvia Coco, Mario Buffelli
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Neurobiology of Disease
Subjects:
Glucocorticoid receptor
Glucocorticoids
Hippocampus
Microglia
Dendritic spines
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302360

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