Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relations...

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Main Authors:	Han-jie Liu, Hui-min Hu, Guan-zhang Li, Ying Zhang, Fan Wu, Xiu Liu, Kuan-yu Wang, Chuan-bao Zhang, Tao Jiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-07-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	ferroptosis prognosis glioma gene signature dataset
Online Access:	https://www.frontiersin.org/article/10.3389/fcell.2020.00538/full

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spelling	doaj-6c152743eeb6474481da781032ea98c62020-11-25T03:48:36ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-07-01810.3389/fcell.2020.00538542976Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient ProgressionHan-jie Liu0Hui-min Hu1Guan-zhang Li2Ying Zhang3Fan Wu4Xiu Liu5Kuan-yu Wang6Chuan-bao Zhang7Tao Jiang8Tao Jiang9Tao Jiang10Tao Jiang11Tao Jiang12Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaChinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA), Beijing, ChinaGlioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relationship between ferroptosis-related genes and glioma by analyzing whole transcriptome data from Chinese Glioma Genome Atlas, The Cancer Genome Atlas dataset, GSE16011 dataset, and the Repository of Molecular Brain Neoplasia Data dataset. Nineteen ferroptosis-related genes with clinical and pathological features of glioma were identified as highly correlated. Functional assays in glioma cell lines indicated the association of ferroptosis with temozolomide resistance, autophagy, and glioma cell migration. Therefore, the identified ferroptosis-related genes were significantly correlated with glioma progression.https://www.frontiersin.org/article/10.3389/fcell.2020.00538/fullferroptosisprognosisgliomagene signaturedataset
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Han-jie Liu Hui-min Hu Guan-zhang Li Ying Zhang Fan Wu Xiu Liu Kuan-yu Wang Chuan-bao Zhang Tao Jiang Tao Jiang Tao Jiang Tao Jiang Tao Jiang
spellingShingle	Han-jie Liu Hui-min Hu Guan-zhang Li Ying Zhang Fan Wu Xiu Liu Kuan-yu Wang Chuan-bao Zhang Tao Jiang Tao Jiang Tao Jiang Tao Jiang Tao Jiang Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression Frontiers in Cell and Developmental Biology ferroptosis prognosis glioma gene signature dataset
author_facet	Han-jie Liu Hui-min Hu Guan-zhang Li Ying Zhang Fan Wu Xiu Liu Kuan-yu Wang Chuan-bao Zhang Tao Jiang Tao Jiang Tao Jiang Tao Jiang Tao Jiang
author_sort	Han-jie Liu
title	Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_short	Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_full	Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_fullStr	Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_full_unstemmed	Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression
title_sort	ferroptosis-related gene signature predicts glioma cell death and glioma patient progression
publisher	Frontiers Media S.A.
series	Frontiers in Cell and Developmental Biology
issn	2296-634X
publishDate	2020-07-01
description	Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relationship between ferroptosis-related genes and glioma by analyzing whole transcriptome data from Chinese Glioma Genome Atlas, The Cancer Genome Atlas dataset, GSE16011 dataset, and the Repository of Molecular Brain Neoplasia Data dataset. Nineteen ferroptosis-related genes with clinical and pathological features of glioma were identified as highly correlated. Functional assays in glioma cell lines indicated the association of ferroptosis with temozolomide resistance, autophagy, and glioma cell migration. Therefore, the identified ferroptosis-related genes were significantly correlated with glioma progression.
topic	ferroptosis prognosis glioma gene signature dataset
url	https://www.frontiersin.org/article/10.3389/fcell.2020.00538/full
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Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

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