Aβ Internalization by Neurons and Glia

In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an...

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Main Authors: Amany Mohamed, Elena Posse de Chaves
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Alzheimer's Disease
Online Access:http://dx.doi.org/10.4061/2011/127984
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spelling doaj-6c0eda901bde44099942a6321a3e9ed32020-11-25T00:48:56ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-02522011-01-01201110.4061/2011/127984127984Aβ Internalization by Neurons and GliaAmany Mohamed0Elena Posse de Chaves1Department of Pharmacology, University of Alberta, Edmonton, AB, T6G 2H7, CanadaDepartment of Pharmacology, University of Alberta, Edmonton, AB, T6G 2H7, CanadaIn the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an important role in the pathogenesis of Alzheimer's disease. Intraneuronal Aβ originates from intracellular cleavage of APP and from Aβ internalization from the extracellular milieu. We discuss here the different molecular mechanisms that are responsible for Aβ internalization in neurons and the links between Aβ internalization and neuronal dysfunction and death. A brief description of Aβ uptake by glia is also presented.http://dx.doi.org/10.4061/2011/127984
collection DOAJ
language English
format Article
sources DOAJ
author Amany Mohamed
Elena Posse de Chaves
spellingShingle Amany Mohamed
Elena Posse de Chaves
Aβ Internalization by Neurons and Glia
International Journal of Alzheimer's Disease
author_facet Amany Mohamed
Elena Posse de Chaves
author_sort Amany Mohamed
title Aβ Internalization by Neurons and Glia
title_short Aβ Internalization by Neurons and Glia
title_full Aβ Internalization by Neurons and Glia
title_fullStr Aβ Internalization by Neurons and Glia
title_full_unstemmed Aβ Internalization by Neurons and Glia
title_sort aβ internalization by neurons and glia
publisher Hindawi Limited
series International Journal of Alzheimer's Disease
issn 2090-0252
publishDate 2011-01-01
description In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an important role in the pathogenesis of Alzheimer's disease. Intraneuronal Aβ originates from intracellular cleavage of APP and from Aβ internalization from the extracellular milieu. We discuss here the different molecular mechanisms that are responsible for Aβ internalization in neurons and the links between Aβ internalization and neuronal dysfunction and death. A brief description of Aβ uptake by glia is also presented.
url http://dx.doi.org/10.4061/2011/127984
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