Aβ Internalization by Neurons and Glia
In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an...
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Series: | International Journal of Alzheimer's Disease |
Online Access: | http://dx.doi.org/10.4061/2011/127984 |
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doaj-6c0eda901bde44099942a6321a3e9ed32020-11-25T00:48:56ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-02522011-01-01201110.4061/2011/127984127984Aβ Internalization by Neurons and GliaAmany Mohamed0Elena Posse de Chaves1Department of Pharmacology, University of Alberta, Edmonton, AB, T6G 2H7, CanadaDepartment of Pharmacology, University of Alberta, Edmonton, AB, T6G 2H7, CanadaIn the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an important role in the pathogenesis of Alzheimer's disease. Intraneuronal Aβ originates from intracellular cleavage of APP and from Aβ internalization from the extracellular milieu. We discuss here the different molecular mechanisms that are responsible for Aβ internalization in neurons and the links between Aβ internalization and neuronal dysfunction and death. A brief description of Aβ uptake by glia is also presented.http://dx.doi.org/10.4061/2011/127984 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amany Mohamed Elena Posse de Chaves |
spellingShingle |
Amany Mohamed Elena Posse de Chaves Aβ Internalization by Neurons and Glia International Journal of Alzheimer's Disease |
author_facet |
Amany Mohamed Elena Posse de Chaves |
author_sort |
Amany Mohamed |
title |
Aβ Internalization by Neurons and Glia |
title_short |
Aβ Internalization by Neurons and Glia |
title_full |
Aβ Internalization by Neurons and Glia |
title_fullStr |
Aβ Internalization by Neurons and Glia |
title_full_unstemmed |
Aβ Internalization by Neurons and Glia |
title_sort |
aβ internalization by neurons and glia |
publisher |
Hindawi Limited |
series |
International Journal of Alzheimer's Disease |
issn |
2090-0252 |
publishDate |
2011-01-01 |
description |
In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an important role in the pathogenesis of Alzheimer's disease. Intraneuronal Aβ originates from intracellular cleavage of APP and from Aβ internalization from the extracellular milieu. We discuss here the different molecular mechanisms that are responsible for Aβ internalization in neurons and the links between Aβ internalization and neuronal dysfunction and death. A brief description of Aβ uptake by glia is also presented. |
url |
http://dx.doi.org/10.4061/2011/127984 |
work_keys_str_mv |
AT amanymohamed abinternalizationbyneuronsandglia AT elenapossedechaves abinternalizationbyneuronsandglia |
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