Epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study

Background: Present study aimed to investigate immunohistochemical parameters in post-surgical cases of invasive breast cancer. Methods: In this single center cross-sectional study we investigated ethnicity, familial history, type of cancer, stage of cancer, lymph node positivity, bilateral involvem...

Full description

Bibliographic Details
Main Authors: Sayad Soheila, Yasin Ahmadi Seyyed Amir, Nekouian Reza, Panahi Mahshid, Anbari Khatereh
Format: Article
Language:English
Published: Institute of Oncology, Sremska Kamenica, Serbia 2020-01-01
Series:Archive of Oncology
Subjects:
Online Access:https://scindeks-clanci.ceon.rs/data/pdf/0354-7310/2020/0354-73102001006S.pdf
id doaj-6bfa118b0767430aa59691ed2958fd1d
record_format Article
spelling doaj-6bfa118b0767430aa59691ed2958fd1d2020-11-25T01:45:13ZengInstitute of Oncology, Sremska Kamenica, SerbiaArchive of Oncology0354-73101450-95202020-01-01261690354-73102001006SEpidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional studySayad Soheila0Yasin Ahmadi Seyyed Amir1Nekouian Reza2Panahi Mahshid3Anbari Khatereh4Iran University of Medical Sciences, Firoozgar Clinical Research Development Center (FCRDC), Department of Surgery, Tehran, Iran + Iran University of Medical Sciences, Institute of Endocrinology and Metabolism, Pediatric Growth and Development Research Center, Tehran, IranIran University of Medical Sciences, Student Research Committee, Tehran, Iran + Iran University of Medical Sciences, Institute of Endocrinology and Metabolism, Pediatric Growth and Development Research Center, Tehran, IranIran University of Medical Sciences, Institute of Endocrinology and Metabolism, Pediatric Growth and Development Research Center, Tehran, IranIran University of Medical Sciences, Firoozgar Clinical Research Development Center (FCRDC), Department of Pathology, Tehran, IranLorestan University of Medical Sciences, Social Determinants of Health Research Center, Khorramabad, IranBackground: Present study aimed to investigate immunohistochemical parameters in post-surgical cases of invasive breast cancer. Methods: In this single center cross-sectional study we investigated ethnicity, familial history, type of cancer, stage of cancer, lymph node positivity, bilateral involvement, metastasis and immunohistochemical parameters (estrogen and progesterone receptor, human epidermal growth factor receptor 2, as well as frequency of triple positive and triple negative patients merely based on immunohistochemical parameters). Results: Frequency of positive familial history was 27.42% (16.31-38.52%). Lymph node involvement was detected in 55.93% (43.26-68.60%) of the cases. Frequency of positive HER2 was 38.60% (25.96-51.23%). There were 17.54% (7.67-27.42%) of triple positive and 7.02% (0.39-13.65%) of triple negative cases. The most common stage at the time of diagnosis was stage 3 with 43.33% (30.79-55.87%) frequency. In Lur/Lak population higher frequency of positive HER2 cases was detected whereas in Mazani population frequency of positive HER2 cases was low (p=0.0291). Conclusions: These results could contribute to understanding of breast cancer patterns among different ethnicities. In order to draw clear conclusion future investigations have to be done in several health centers, for longer time periods and with larger number of patients.https://scindeks-clanci.ceon.rs/data/pdf/0354-7310/2020/0354-73102001006S.pdfbreast cancerestrogen receptorher2triple negativepathologyiran
collection DOAJ
language English
format Article
sources DOAJ
author Sayad Soheila
Yasin Ahmadi Seyyed Amir
Nekouian Reza
Panahi Mahshid
Anbari Khatereh
spellingShingle Sayad Soheila
Yasin Ahmadi Seyyed Amir
Nekouian Reza
Panahi Mahshid
Anbari Khatereh
Epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study
Archive of Oncology
breast cancer
estrogen receptor
her2
triple negative
pathology
iran
author_facet Sayad Soheila
Yasin Ahmadi Seyyed Amir
Nekouian Reza
Panahi Mahshid
Anbari Khatereh
author_sort Sayad Soheila
title Epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study
title_short Epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study
title_full Epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study
title_fullStr Epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study
title_full_unstemmed Epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study
title_sort epidemiological and pathological characteristics of postsurgical cases of invasive breast cancer among ethnicities of iran in 2018: a single center cross-sectional study
publisher Institute of Oncology, Sremska Kamenica, Serbia
series Archive of Oncology
issn 0354-7310
1450-9520
publishDate 2020-01-01
description Background: Present study aimed to investigate immunohistochemical parameters in post-surgical cases of invasive breast cancer. Methods: In this single center cross-sectional study we investigated ethnicity, familial history, type of cancer, stage of cancer, lymph node positivity, bilateral involvement, metastasis and immunohistochemical parameters (estrogen and progesterone receptor, human epidermal growth factor receptor 2, as well as frequency of triple positive and triple negative patients merely based on immunohistochemical parameters). Results: Frequency of positive familial history was 27.42% (16.31-38.52%). Lymph node involvement was detected in 55.93% (43.26-68.60%) of the cases. Frequency of positive HER2 was 38.60% (25.96-51.23%). There were 17.54% (7.67-27.42%) of triple positive and 7.02% (0.39-13.65%) of triple negative cases. The most common stage at the time of diagnosis was stage 3 with 43.33% (30.79-55.87%) frequency. In Lur/Lak population higher frequency of positive HER2 cases was detected whereas in Mazani population frequency of positive HER2 cases was low (p=0.0291). Conclusions: These results could contribute to understanding of breast cancer patterns among different ethnicities. In order to draw clear conclusion future investigations have to be done in several health centers, for longer time periods and with larger number of patients.
topic breast cancer
estrogen receptor
her2
triple negative
pathology
iran
url https://scindeks-clanci.ceon.rs/data/pdf/0354-7310/2020/0354-73102001006S.pdf
work_keys_str_mv AT sayadsoheila epidemiologicalandpathologicalcharacteristicsofpostsurgicalcasesofinvasivebreastcanceramongethnicitiesofiranin2018asinglecentercrosssectionalstudy
AT yasinahmadiseyyedamir epidemiologicalandpathologicalcharacteristicsofpostsurgicalcasesofinvasivebreastcanceramongethnicitiesofiranin2018asinglecentercrosssectionalstudy
AT nekouianreza epidemiologicalandpathologicalcharacteristicsofpostsurgicalcasesofinvasivebreastcanceramongethnicitiesofiranin2018asinglecentercrosssectionalstudy
AT panahimahshid epidemiologicalandpathologicalcharacteristicsofpostsurgicalcasesofinvasivebreastcanceramongethnicitiesofiranin2018asinglecentercrosssectionalstudy
AT anbarikhatereh epidemiologicalandpathologicalcharacteristicsofpostsurgicalcasesofinvasivebreastcanceramongethnicitiesofiranin2018asinglecentercrosssectionalstudy
_version_ 1725024361506668544