Attenuation of Human Respiratory Viruses by Synonymous Genome Recoding

Attenuation of Human Respiratory Viruses by Synonymous Genome Recoding

Using computer algorithms and commercial DNA synthesis, one or more ORFs of a microbial pathogen such as a virus can be recoded and deoptimized by several strategies that may involve the introduction of up to thousands of nucleotide (nt) changes without affecting amino acid (aa) coding. The synonymo...

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Bibliographic Details
Main Authors:	Cyril Le Nouën, Peter L. Collins, Ursula J. Buchholz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-06-01
Series:	Frontiers in Immunology
Subjects:	human respiratory virus respiratory syncytial virus influenza virus vaccine genome recoding synonymous codon deoptimization
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01250/full

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