Trojan Horse Delivery of 4,4′‐Dimethoxychalcone for Parkinsonian Neuroprotection

Trojan Horse Delivery of 4,4′‐Dimethoxychalcone for Parkinsonian Neuroprotection

Abstract Parkinson's disease (PD) is characterized by the progressive deterioration of dopamine (DA) neurons, and therapeutic endeavors are aimed at preventing DA loss. However, lack of effective brain delivery approaches limits this strategy. In this study, a “Trojan horse” system is used for...

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Bibliographic Details
Main Authors: Wenlong Zhang, Huaqing Chen, Liuyan Ding, Junwei Gong, Mengran Zhang, Wenyuan Guo, Pingyi Xu, Shiying Li, Yunlong Zhang
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Advanced Science
Subjects:
blood brain barrier
brain targeted delivery
DMC
neuroinflammation
oxidative stress
TH ubiquitination
Online Access:https://doi.org/10.1002/advs.202004555

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