Clinical and immunological aspects of extracorporeal photochemotherapy for psoriasis and psoriatic arthritis

• Main Authors: V A Molochkov, A V Kil'diushevskiĭ, A V Molochkov, O V Karzanov, E S Iakubovskaia, V A Fedulkina
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2012-10-01
• Series: Терапевтический архив
• Subjects: psoriasis; psoriatic arthritis; extracorporeal photochemotherapy; photopheresis
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31144
• ISSN: 0040-3660; 2309-5342

Aim. To evaluate the clinical efficiency of extracorporeal photochemotherapy (EPCT) in the treatment of psoriasis (Ps) and Ps associated with psoriatic arthritis (PsA). Subjects and methods. Ninety-three patients with different forms of psoriasis were examined. A study group (SG) comprised 52 patients who were treated with EPCT; a control group (CG) included 41 patients. All the patients received pharmacotherapy generally accepted for these diseases. The SG patients were given additionally EPCT (the patient took 8-methoxypsoralen in a dose of 0.6 mg/kg 1.5-2 hours before the procedure). Mononuclear cells were isolated from the patients' blood in the intermittent-line mode on a Haemonetics MCS+ cell separator. The cell suspension was irradiated with ultraviolet light A (λ=320-400 nm) on a JULIA irradiator at 10-15 ml/min for 30 min and reinfused in the patient. The course of therapy consisted of 4 sessions performed on alternate days. Results. A varying positive effect was obtained in 49 (94%) SG patients; the mean PASI scores fell from 19.7±3.4 to 6.7±2.1 (p