Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy

Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy

Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and mol...

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Main Authors: Michael Chamberlin, Sophia Khan, Cristal Hernandez, Markku Miettinen, Jun S. Wei, Javed Khan, John Glod, Lindsay Rowe, Aradhana Kaushal
Format: Article
Language:English
Published: Karger Publishers 2021-02-01
Series:Case Reports in Oncology
Subjects:
aneurysmal fibrous histiocytoma
radiation
pazopanib
protein kinase c inhibitor
midostaurin
Online Access:https://www.karger.com/Article/FullText/511073
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spelling doaj-6bdac3fa6dc046b59e780b839e45ce302021-03-04T16:01:35ZengKarger PublishersCase Reports in Oncology1662-65752021-02-01141172310.1159/000511073511073Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted TherapyMichael ChamberlinSophia KhanCristal HernandezMarkku MiettinenJun S. WeiJaved KhanJohn GlodLindsay RoweAradhana KaushalAneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and molecularly targeted therapy. To our knowledge, this is the first report describing either radiation therapy and palliation or the use of targeted therapy in this uncommon malignancy and can provide insight into future therapeutic strategies.https://www.karger.com/Article/FullText/511073aneurysmal fibrous histiocytomaradiationpazopanibprotein kinase c inhibitormidostaurin
collection DOAJ
language English
format Article
sources DOAJ
author Michael Chamberlin
Sophia Khan
Cristal Hernandez
Markku Miettinen
Jun S. Wei
Javed Khan
John Glod
Lindsay Rowe
Aradhana Kaushal
spellingShingle Michael Chamberlin
Sophia Khan
Cristal Hernandez
Markku Miettinen
Jun S. Wei
Javed Khan
John Glod
Lindsay Rowe
Aradhana Kaushal
Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy
Case Reports in Oncology
aneurysmal fibrous histiocytoma
radiation
pazopanib
protein kinase c inhibitor
midostaurin
author_facet Michael Chamberlin
Sophia Khan
Cristal Hernandez
Markku Miettinen
Jun S. Wei
Javed Khan
John Glod
Lindsay Rowe
Aradhana Kaushal
author_sort Michael Chamberlin
title Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy
title_short Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy
title_full Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy
title_fullStr Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy
title_full_unstemmed Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy
title_sort aneurysmal fibrous histiocytoma: a large soft tissue tumor with metastases treated with palliative radiation therapy and targeted therapy
publisher Karger Publishers
series Case Reports in Oncology
issn 1662-6575
publishDate 2021-02-01
description Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and molecularly targeted therapy. To our knowledge, this is the first report describing either radiation therapy and palliation or the use of targeted therapy in this uncommon malignancy and can provide insight into future therapeutic strategies.
topic aneurysmal fibrous histiocytoma
radiation
pazopanib
protein kinase c inhibitor
midostaurin
url https://www.karger.com/Article/FullText/511073
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