Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy

Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy

Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and mol...

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Bibliographic Details
Main Authors: Michael Chamberlin, Sophia Khan, Cristal Hernandez, Markku Miettinen, Jun S. Wei, Javed Khan, John Glod, Lindsay Rowe, Aradhana Kaushal
Format: Article
Language:English
Published: Karger Publishers 2021-02-01
Series:Case Reports in Oncology
Subjects:
aneurysmal fibrous histiocytoma
radiation
pazopanib
protein kinase c inhibitor
midostaurin
Online Access:https://www.karger.com/Article/FullText/511073
Description
Summary:Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and molecularly targeted therapy. To our knowledge, this is the first report describing either radiation therapy and palliation or the use of targeted therapy in this uncommon malignancy and can provide insight into future therapeutic strategies.
ISSN:1662-6575

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