Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production.
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| Format: | Article |
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Nature Publishing Group
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10934 |
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doaj-6bcc873a3691474593b9a5309921326e2021-05-11T10:43:34ZengNature Publishing GroupNature Communications2041-17232016-03-017111010.1038/ncomms10934Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 systemTaek-Chin Cheong0Mara Compagno1Roberto Chiarle2Department of Pathology, Children’s Hospital Boston and Harvard Medical SchoolDepartment of Pathology, Children’s Hospital Boston and Harvard Medical SchoolDepartment of Pathology, Children’s Hospital Boston and Harvard Medical SchoolCRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production.https://doi.org/10.1038/ncomms10934 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Taek-Chin Cheong Mara Compagno Roberto Chiarle |
| spellingShingle |
Taek-Chin Cheong Mara Compagno Roberto Chiarle Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system Nature Communications |
| author_facet |
Taek-Chin Cheong Mara Compagno Roberto Chiarle |
| author_sort |
Taek-Chin Cheong |
| title |
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system |
| title_short |
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system |
| title_full |
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system |
| title_fullStr |
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system |
| title_full_unstemmed |
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system |
| title_sort |
editing of mouse and human immunoglobulin genes by crispr-cas9 system |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-03-01 |
| description |
CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up possibilities for research and antibody production. |
| url |
https://doi.org/10.1038/ncomms10934 |
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1721447686852313088 |