Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis

Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis

S100 calcium-binding protein A8 (S100A8), a danger-associated molecular pattern, has emerged as an important mediator of the pro-inflammatory response. Some S100 proteins play a prominent role in neuroinflammatory disorders and increase the secretion of pro-inflammatory cytokines in microglial cells...

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Bibliographic Details
Main Authors: Ji Sun Ha, Hye-Rim Choi, In Sik Kim, Eun-A Kim, Sung-Woo Cho, Seung-Ju Yang
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
S100A8
microglia
inflammasome
hypoxia
neuronal apoptosis
COX-2
Online Access:https://www.mdpi.com/1422-0067/22/3/1205

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