Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth

Complement Protein C1q Binds to Hyaluronic Acid in the Malignant Pleural Mesothelioma Microenvironment and Promotes Tumor Growth

C1q is the first recognition subcomponent of the complement classical pathway, which acts toward the clearance of pathogens and apoptotic cells. C1q is also known to modulate a range of functions of immune and non-immune cells, and has been shown to be involved in placental development and sensorial...

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Main Authors: Chiara Agostinis, Romana Vidergar, Beatrice Belmonte, Alessandro Mangogna, Leonardo Amadio, Pietro Geri, Violetta Borelli, Fabrizio Zanconati, Francesco Tedesco, Marco Confalonieri, Claudio Tripodo, Uday Kishore, Roberta Bulla
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
complement system
malignant pleural mesothelioma
hyaluronic acid
mesothelioma cells
C1q
cancer
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01559/full

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