Effect of alprostadil combined with fosinopril therapy on renal function and oxidative stress in patients with diabetic nephropathy
bjective: To analyze the effect of alprostadil combined with fosinopril therapy on renal function and oxidative stress in patients with diabetic nephropathy. Methods: A total of 80 cases of patients with diabetic nephropathy were included in this study and randomly divided into observation group...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2016-08-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201616/11.pdf |
| Summary: | bjective: To analyze the effect of alprostadil combined with fosinopril therapy on renal
function and oxidative stress in patients with diabetic nephropathy. Methods: A total of 80
cases of patients with diabetic nephropathy were included in this study and randomly divided
into observation group and control group (n=40), control group received fosinopril therapy
alone and observation group received alprostadil combined with fosinopril therapy. Differences
in serum renal function indexes, renal damage indexes of ultrasound contrast, oxidative stress
indexes, etc were compared between two groups. Results: Serum BUN, Scr and 24 h urine
protein values of observation group were lower than those of control group; the left kidney
and right kidney AUC and TTP values were lower than those of control group while DPI
value was higher than that of control group; serum 8-OHdG and MDA values were lower than
those of control group while SOD and T-AOC values were higher than those of control group.
Conclusion: Alprostadil combined with fosinopril therapy can reduce renal cortex damage in
patients with diabetic nephropathy, and plays a positive role in optimizing renal function and
reducing systemic oxidative stress. |
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| ISSN: | 1007-1237 1007-1237 |