The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

The conserved DAF-16/FOXO transcription factors and SIR-2.1/SIRT1 deacetylases are critical for diverse biological processes, particularly longevity and stress response; and complex regulation of DAF-16/FOXO by SIR-2.1/SIRT1 is central to appropriate biological outcomes. Caenorhabditis elegans Host...

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Bibliographic Details
Main Authors: Gizem Rizki, Terri Naoko Iwata, Ji Li, Christian G Riedel, Colette Lafontaine Picard, Max Jan, Coleen T Murphy, Siu Sylvia Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3164695?pdf=render

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