An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

Connexin40 (Cx40)-containing gap-junction channels are expressed in the atrial myocardium and provide a low-resistance passage for rapid impulse propagation. A germline mutation in the GJA5 gene, which encodes Cx40, resulting in a truncated Cx40 (Q49X) was identified in a large Chinese family with l...

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Bibliographic Details
Main Authors: Yiguo Sun, Xiaoling Tong, Honghong Chen, Tao Huang, Qing Shao, Weixiong Huang, Dale W. Laird, Donglin Bai
Format: Article
Language:English
Published: The Company of Biologists 2014-05-01
Series:Disease Models & Mechanisms
Subjects:
Atrial fibrillation
Genetics
Gap junctions
Connexin40
Germline mutation
Online Access:http://dmm.biologists.org/content/7/5/561

Internet

http://dmm.biologists.org/content/7/5/561

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