Interplay of cholesterol, membrane bilayers and the AT1R: A cholesterol consensus motif on AT1R is revealed

Interplay of cholesterol, membrane bilayers and the AT1R: A cholesterol consensus motif on AT1R is revealed

Hypertension, mediated by the Angiotensin II receptor type 1 (AT1R), is still the major cause of premature death despite the discovery of novel therapeutics, highlighting the importance of an in depth understanding of the drug-AT1R recognition mechanisms coupled with the impact of the membrane envir...

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Bibliographic Details
Main Authors: Sofia Kiriakidi, Christos Chatzigiannis, Christina Papaemmanouil, Andreas G. Tzakos, Zoe Cournia, Thomas Mavromoustakos
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Candesartan
AT1R
Cholesterol
CCM
Molecular Dynamics
DOSY
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020305092

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