THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS

THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS

Abstract: the aim of our research was assessment of the cumulative risk of disorders of metabolism of folic acid in the development of the congenital defect fetus (CDF) in women with epilepsy and receiving antiepileptic drugs (AEDs). Materials and Methods: the study included 124 cases of pregnancy....

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Main Authors: D. V. Dmitrenko, N. A. Shnayder, Y. B. Govorina, A. V. Muravievа, K. A. Gazenkampf
Format: Article
Language:Russian
Published: IRBIS LLC 2016-05-01
Series:Эпилепсия и пароксизмальные состояния
Subjects:
epilepsy
folic acid
antiepileptic drugs
congenital defect fetus
teratogenesis
Online Access:https://www.epilepsia.su/jour/article/view/71
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spelling doaj-6b8e64cb3cf04bfc8fa5bd419dd2dba32021-07-28T13:43:31ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882016-05-0164162270THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGSD. V. Dmitrenko0N. A. Shnayder1Y. B. Govorina2A. V. Muravievа3K. A. Gazenkampf4Krasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, KrasnoyarskKrasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, KrasnoyarskKrasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, KrasnoyarskKrasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, KrasnoyarskKrasnoyarsk State Medical University; University Clinic, Nneurology Center of epileptology, neurogenetics and brain research, KrasnoyarskAbstract: the aim of our research was assessment of the cumulative risk of disorders of metabolism of folic acid in the development of the congenital defect fetus (CDF) in women with epilepsy and receiving antiepileptic drugs (AEDs). Materials and Methods: the study included 124 cases of pregnancy. Results: 54.7% of the daily doses of AEDs exceeded teratogenic levels; at 4.9% - registered the CDF. In 57.1% cases - the CDF associated with hereditary metabolic disorders of folic acid. Conclusions. Women which receive AEDs and have hereditary metabolic disorders of metabolism of folic acid are at increased risk group of developing congenital malformations.https://www.epilepsia.su/jour/article/view/71epilepsyfolic acidantiepileptic drugscongenital defect fetusteratogenesis
collection DOAJ
language Russian
format Article
sources DOAJ
author D. V. Dmitrenko
N. A. Shnayder
Y. B. Govorina
A. V. Muravievа
K. A. Gazenkampf
spellingShingle D. V. Dmitrenko
N. A. Shnayder
Y. B. Govorina
A. V. Muravievа
K. A. Gazenkampf
THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS
Эпилепсия и пароксизмальные состояния
epilepsy
folic acid
antiepileptic drugs
congenital defect fetus
teratogenesis
author_facet D. V. Dmitrenko
N. A. Shnayder
Y. B. Govorina
A. V. Muravievа
K. A. Gazenkampf
author_sort D. V. Dmitrenko
title THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS
title_short THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS
title_full THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS
title_fullStr THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS
title_full_unstemmed THE ROLE OF HEREDITARY DISORDERS OF METABOLISM of FOLIC ACID IN THE DEVELOPMENT OF CONGENITAL DEFECT FETUS IN WOMEN WITH EPILEPSY AND RECEIVING ANTIEPILEPTIC DRUGS
title_sort role of hereditary disorders of metabolism of folic acid in the development of congenital defect fetus in women with epilepsy and receiving antiepileptic drugs
publisher IRBIS LLC
series Эпилепсия и пароксизмальные состояния
issn 2077-8333
2311-4088
publishDate 2016-05-01
description Abstract: the aim of our research was assessment of the cumulative risk of disorders of metabolism of folic acid in the development of the congenital defect fetus (CDF) in women with epilepsy and receiving antiepileptic drugs (AEDs). Materials and Methods: the study included 124 cases of pregnancy. Results: 54.7% of the daily doses of AEDs exceeded teratogenic levels; at 4.9% - registered the CDF. In 57.1% cases - the CDF associated with hereditary metabolic disorders of folic acid. Conclusions. Women which receive AEDs and have hereditary metabolic disorders of metabolism of folic acid are at increased risk group of developing congenital malformations.
topic epilepsy
folic acid
antiepileptic drugs
congenital defect fetus
teratogenesis
url https://www.epilepsia.su/jour/article/view/71
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