RYR2 Mutations Are Associated With Benign Epilepsy of Childhood With Centrotemporal Spikes With or Without Arrhythmia

RYR2 Mutations Are Associated With Benign Epilepsy of Childhood With Centrotemporal Spikes With or Without Arrhythmia

RYR2 encodes ryanodine receptor 2 protein (RYR-2) that is mainly located on endoplasmic reticulum membrane and regulates intracellular calcium concentration. The RYR-2 protein is ubiquitously distributed and highly expressed in the heart and brain. Previous studies have identified the RYR2 mutations...

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Bibliographic Details
Main Authors: Mei-Gang Ma, Xiao-Rong Liu, Yuan Wu, Jie Wang, Bing-Mei Li, Yi-Wu Shi, Tao Su, Bin Li, De-Tian Liu, Yong-Hong Yi, Wei-Ping Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Neuroscience
Subjects:
RYR2
mutations
epilepsy
BECTS
arrhythmia
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.629610/full

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