Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery

Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery

Identification of optimal transcription factor expression patterns to direct cellular differentiation along a desired pathway presents significant challenges. We demonstrate massively combinatorial screening of temporally-varying mRNA transcription factors to direct differentiation of neural progeni...

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Bibliographic Details
Main Authors: Sayyed M Azimi, Steven D Sheridan, Mostafa Ghannad-Rezaie, Peter M Eimon, Mehmet Fatih Yanik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
neuron
stem cell
reprogramming
high-throughput
screening
transcription factors
Online Access:https://elifesciences.org/articles/31922

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