Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway

Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway

Palmitoylethanolamide (PEA) is an endogenous lipid mediator with powerful anti-inflammatory and analgesic functions. PEA can be hydrolyzed by a lysosomal enzyme N-acylethanolamine acid amidase (NAAA), which is highly expressed in macrophages and other immune cells. The pharmacological inhibition of...

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Bibliographic Details
Main Authors: Wenhui Jin, Longhe Yang, Zhiwei Yi, Hua Fang, Weizhu Chen, Zhuan Hong, Yiping Zhang, Guangya Zhang, Long Li
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Marine Drugs
Subjects:
fucoxanthinol
inflammation
NAAA
PEA
PPAR-α
Online Access:https://www.mdpi.com/1660-3397/18/4/222

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