Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges
Previously considered a degenerative process, cardiovascular calcification is now established as an active process that is regulated in several ways by lipids, phospholipids, and lipoproteins. These compounds serve many of the same functions in vascular and valvular calcification as they do in skele...
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doaj-6b7fd763703f4e0794d9654e5cc2fad72020-11-24T22:52:09ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2018-11-01510.3389/fcvm.2018.00172420761Lipoproteins in Cardiovascular Calcification: Potential Targets and ChallengesYin Tintut0Yin Tintut1Yin Tintut2Jeffrey J. Hsu3Linda L. Demer4Linda L. Demer5Linda L. Demer6Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United StatesPreviously considered a degenerative process, cardiovascular calcification is now established as an active process that is regulated in several ways by lipids, phospholipids, and lipoproteins. These compounds serve many of the same functions in vascular and valvular calcification as they do in skeletal bone calcification. Hyperlipidemia leads to accumulation of lipoproteins in the subendothelial space of cardiovascular tissues, which leads to formation of mildly oxidized phospholipids, which are known bioactive factors in vascular cell calcification. One lipoprotein of particular interest is Lp(a), which showed genome-wide significance for the presence of aortic valve calcification and stenosis. It carries an important enzyme, autotaxin, which produces lysophosphatidic acid (LPA), and thus has a key role in inflammation among other functions. Matrix vesicles, extruded from the plasma membrane of cells, are the sites of initiation of mineral formation. Phosphatidylserine, a phospholipid in the membranes of matrix vesicles, is believed to complex with calcium and phosphate ions, creating a nidus for hydroxyapatite crystal formation in cardiovascular as well as in skeletal bone mineralization. This review focuses on the contributions of lipids, phospholipids, lipoproteins, and autotaxin in cardiovascular calcification, and discusses possible therapeutic targets.https://www.frontiersin.org/article/10.3389/fcvm.2018.00172/fulllipoproteinscalcificationLp(a)autotaxinosteogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yin Tintut Yin Tintut Yin Tintut Jeffrey J. Hsu Linda L. Demer Linda L. Demer Linda L. Demer |
spellingShingle |
Yin Tintut Yin Tintut Yin Tintut Jeffrey J. Hsu Linda L. Demer Linda L. Demer Linda L. Demer Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges Frontiers in Cardiovascular Medicine lipoproteins calcification Lp(a) autotaxin osteogenesis |
author_facet |
Yin Tintut Yin Tintut Yin Tintut Jeffrey J. Hsu Linda L. Demer Linda L. Demer Linda L. Demer |
author_sort |
Yin Tintut |
title |
Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges |
title_short |
Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges |
title_full |
Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges |
title_fullStr |
Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges |
title_full_unstemmed |
Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges |
title_sort |
lipoproteins in cardiovascular calcification: potential targets and challenges |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2018-11-01 |
description |
Previously considered a degenerative process, cardiovascular calcification is now established as an active process that is regulated in several ways by lipids, phospholipids, and lipoproteins. These compounds serve many of the same functions in vascular and valvular calcification as they do in skeletal bone calcification. Hyperlipidemia leads to accumulation of lipoproteins in the subendothelial space of cardiovascular tissues, which leads to formation of mildly oxidized phospholipids, which are known bioactive factors in vascular cell calcification. One lipoprotein of particular interest is Lp(a), which showed genome-wide significance for the presence of aortic valve calcification and stenosis. It carries an important enzyme, autotaxin, which produces lysophosphatidic acid (LPA), and thus has a key role in inflammation among other functions. Matrix vesicles, extruded from the plasma membrane of cells, are the sites of initiation of mineral formation. Phosphatidylserine, a phospholipid in the membranes of matrix vesicles, is believed to complex with calcium and phosphate ions, creating a nidus for hydroxyapatite crystal formation in cardiovascular as well as in skeletal bone mineralization. This review focuses on the contributions of lipids, phospholipids, lipoproteins, and autotaxin in cardiovascular calcification, and discusses possible therapeutic targets. |
topic |
lipoproteins calcification Lp(a) autotaxin osteogenesis |
url |
https://www.frontiersin.org/article/10.3389/fcvm.2018.00172/full |
work_keys_str_mv |
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