Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein

Parkinson’s disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive disease progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation and impairment of protein degradation systems. Dysfunction of th...

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Bibliographic Details
Main Authors: Eduard eBentea, Anke eVan der Perren, Joeri eVan Liefferinge, Anissa eEl Arfani, Giulia eAlbertini, Thomas eDemuyser, Ellen eMerckx, Yvette eMichotte, Ilse eSmolders, Veerle eBaekelandt, Ann eMassie
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Parkinson's disease
mouse model
Proteasome
α-Synuclein
Lactacystin
Non-motor behavior
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00068/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00068/full

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