Pervasive Modulation of Obesity Risk by the Environment and Genomic Background

Pervasive Modulation of Obesity Risk by the Environment and Genomic Background

The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incid...

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Bibliographic Details
Main Authors: Sini Nagpal, Greg Gibson, Urko M. Marigorta
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Genes
Subjects:
diseases of affluence
body mass index
gene-by-environment interactions
genome-wide association studies (GWAS)
polygenic scores (PGS)
epistasis
allele expressivity
UK Biobank
Online Access:http://www.mdpi.com/2073-4425/9/8/411

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