Predicting and Promoting Human Bone Marrow MSC Chondrogenesis by Way of TGFβ Receptor Profiles: Toward Personalized Medicine

Predicting and Promoting Human Bone Marrow MSC Chondrogenesis by Way of TGFβ Receptor Profiles: Toward Personalized Medicine

The use of human mesenchymal stromal cells (hMSCs) for cartilage regeneration has been hampered by the inherent donor variation of primary monolayer expanded cells. Although CD markers are typically used to characterize cell populations, there is no correlation between CD marker profile and function...

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Bibliographic Details
Main Authors: René Rothweiler, Valentina Basoli, Fabian Duttenhoefer, David Kubosch, Rainer Schmelzeisen, Brian Johnstone, Mauro Alini, Martin James Stoddart
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mesenchymal stem cell
TGF receptor
chondrogenic differentiation
receptor ratio
personalized medicine
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00618/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00618/full

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