Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their Cytotoxicities

Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their Cytotoxicities

A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, <strong>1</strong>) together with the known alkaloid stigmalactam (<strong>2</strong>), were isolated from <em>Orophe...

Full description

Bibliographic Details
Main Authors: Sanchai Nayyatip, Pak Thaichana, Mongkol Buayairaksa, Wirote Tuntiwechapikul, Puttinan Meepowpan, Narong Nuntasaen, Wilart Pompimon
Format: Article
Language:English
Published: MDPI AG 2012-04-01
Series:International Journal of Molecular Sciences
Subjects:
<em>Orophea enterocarpa</em>
Anonaceae
aristolactam
human colon adenocarcinoma cells
cytotoxicities
Online Access:http://www.mdpi.com/1422-0067/13/4/5010
id doaj-6b6b3a54bfde42e8a06933eb4034bf8d
record_format Article
spelling doaj-6b6b3a54bfde42e8a06933eb4034bf8d2020-11-25T00:02:19ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-04-0113450105018Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their CytotoxicitiesSanchai NayyatipPak ThaichanaMongkol BuayairaksaWirote TuntiwechapikulPuttinan MeepowpanNarong NuntasaenWilart PompimonA new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, <strong>1</strong>) together with the known alkaloid stigmalactam (<strong>2</strong>), were isolated from <em>Orophea enterocarpa</em>. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds <strong>1</strong> and <strong>2</strong> exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC<sub>50</sub> values of 1.68 and 1.32 μM, respectively.http://www.mdpi.com/1422-0067/13/4/5010<em>Orophea enterocarpa</em>Anonaceaearistolactamhuman colon adenocarcinoma cellscytotoxicities
collection DOAJ
language English
format Article
sources DOAJ
author Sanchai Nayyatip
Pak Thaichana
Mongkol Buayairaksa
Wirote Tuntiwechapikul
Puttinan Meepowpan
Narong Nuntasaen
Wilart Pompimon
spellingShingle Sanchai Nayyatip
Pak Thaichana
Mongkol Buayairaksa
Wirote Tuntiwechapikul
Puttinan Meepowpan
Narong Nuntasaen
Wilart Pompimon
Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their Cytotoxicities
International Journal of Molecular Sciences
<em>Orophea enterocarpa</em>
Anonaceae
aristolactam
human colon adenocarcinoma cells
cytotoxicities
author_facet Sanchai Nayyatip
Pak Thaichana
Mongkol Buayairaksa
Wirote Tuntiwechapikul
Puttinan Meepowpan
Narong Nuntasaen
Wilart Pompimon
author_sort Sanchai Nayyatip
title Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their Cytotoxicities
title_short Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their Cytotoxicities
title_full Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their Cytotoxicities
title_fullStr Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their Cytotoxicities
title_full_unstemmed Aristolactam-Type Alkaloids from <em>Orophea enterocarpa</em> and Their Cytotoxicities
title_sort aristolactam-type alkaloids from <em>orophea enterocarpa</em> and their cytotoxicities
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2012-04-01
description A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, <strong>1</strong>) together with the known alkaloid stigmalactam (<strong>2</strong>), were isolated from <em>Orophea enterocarpa</em>. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds <strong>1</strong> and <strong>2</strong> exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC<sub>50</sub> values of 1.68 and 1.32 μM, respectively.
topic <em>Orophea enterocarpa</em>
Anonaceae
aristolactam
human colon adenocarcinoma cells
cytotoxicities
url http://www.mdpi.com/1422-0067/13/4/5010
work_keys_str_mv AT sanchainayyatip aristolactamtypealkaloidsfromltemgtoropheaenterocarpaltemgtandtheircytotoxicities
AT pakthaichana aristolactamtypealkaloidsfromltemgtoropheaenterocarpaltemgtandtheircytotoxicities
AT mongkolbuayairaksa aristolactamtypealkaloidsfromltemgtoropheaenterocarpaltemgtandtheircytotoxicities
AT wirotetuntiwechapikul aristolactamtypealkaloidsfromltemgtoropheaenterocarpaltemgtandtheircytotoxicities
AT puttinanmeepowpan aristolactamtypealkaloidsfromltemgtoropheaenterocarpaltemgtandtheircytotoxicities
AT narongnuntasaen aristolactamtypealkaloidsfromltemgtoropheaenterocarpaltemgtandtheircytotoxicities
AT wilartpompimon aristolactamtypealkaloidsfromltemgtoropheaenterocarpaltemgtandtheircytotoxicities
_version_ 1725438318184759296

Similar Items