A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cells

A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cells

A subset of innate lymphoid cells (ILCs), which produce IL-22 and function in protection against microbial infection, is generated via a local process in gut that is conditioned by commensal bacteria. We investigated the possibility that modulation of ILCs may contribute to the protective effect of...

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Main Authors: Firoz Mian, Nalaayini Kandiah, Marianne Chew, Ali Ashkar, John Bienenstock, Paul Forsythe, Khalil Karimi
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Journal of Functional Foods
Subjects:
Functional foods
Innate lymphoid cells
Lactobacilli
NKp46+ cells
Probiotics
Salmonella
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616000761
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record_format Article
spelling doaj-6b5abccd1b5c4127b356059964438c662021-04-30T07:07:25ZengElsevierJournal of Functional Foods1756-46462016-05-0123329338A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cellsFiroz Mian0Nalaayini Kandiah1Marianne Chew2Ali Ashkar3John Bienenstock4Paul Forsythe5Khalil Karimi6The McMaster Brain – Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, CanadaThe McMaster Brain – Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, CanadaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, CanadaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, CanadaThe McMaster Brain – Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, CanadaThe McMaster Brain – Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada; Department of Medicine, McMaster University, Hamilton, Ontario L8N 4A6, CanadaThe McMaster Brain – Body Institute, McMaster University, Hamilton, Ontario L8N 4A6, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 4A6, Canada; Department of Medicine, McMaster University, Hamilton, Ontario L8N 4A6, Canada; Corresponding author. The McMaster Brain-Body Institute, St. Joseph's Healthcare, 50 Charlton Avenue East, T3304, Hamilton, Ontario L8N 4A6, Canada. Tel.: +905 522 1155 ex 33820; fax: +905 540 6593.A subset of innate lymphoid cells (ILCs), which produce IL-22 and function in protection against microbial infection, is generated via a local process in gut that is conditioned by commensal bacteria. We investigated the possibility that modulation of ILCs may contribute to the protective effect of certain bacteria in relation to pathogen infection. We fed BALB/c mice with L. rhamnosus JB-1 and characterized Peyer's patches NKp46+ cells. Additionally, the effect of feeding L. rhamnosus JB-1 on S. enterica serovar Typhimurium infection was determined. L. rhamnosus JB-1-feeding resulted in lower bacterial loads of Salmonella Typhimurium in the Peyer's patches, mesenteric lymph nodes and colon; and was associated with high levels of IL-22, RORγt, and CD127 expression by NKp46+ cells indicating an increase in ILC3s. Our findings indicate that Lactobacillus feeding regulates the innate lymphoid cell population that may contribute to host defensive function during Salmonella infection.http://www.sciencedirect.com/science/article/pii/S1756464616000761Functional foodsInnate lymphoid cellsLactobacilliNKp46+ cellsProbioticsSalmonella
collection DOAJ
language English
format Article
sources DOAJ
author Firoz Mian
Nalaayini Kandiah
Marianne Chew
Ali Ashkar
John Bienenstock
Paul Forsythe
Khalil Karimi
spellingShingle Firoz Mian
Nalaayini Kandiah
Marianne Chew
Ali Ashkar
John Bienenstock
Paul Forsythe
Khalil Karimi
A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cells
Journal of Functional Foods
Functional foods
Innate lymphoid cells
Lactobacilli
NKp46+ cells
Probiotics
Salmonella
author_facet Firoz Mian
Nalaayini Kandiah
Marianne Chew
Ali Ashkar
John Bienenstock
Paul Forsythe
Khalil Karimi
author_sort Firoz Mian
title A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cells
title_short A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cells
title_full A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cells
title_fullStr A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cells
title_full_unstemmed A probiotic provides protection against acute salmonellosis in mice: Possible role of innate lymphid NKP46+ cells
title_sort probiotic provides protection against acute salmonellosis in mice: possible role of innate lymphid nkp46+ cells
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2016-05-01
description A subset of innate lymphoid cells (ILCs), which produce IL-22 and function in protection against microbial infection, is generated via a local process in gut that is conditioned by commensal bacteria. We investigated the possibility that modulation of ILCs may contribute to the protective effect of certain bacteria in relation to pathogen infection. We fed BALB/c mice with L. rhamnosus JB-1 and characterized Peyer's patches NKp46+ cells. Additionally, the effect of feeding L. rhamnosus JB-1 on S. enterica serovar Typhimurium infection was determined. L. rhamnosus JB-1-feeding resulted in lower bacterial loads of Salmonella Typhimurium in the Peyer's patches, mesenteric lymph nodes and colon; and was associated with high levels of IL-22, RORγt, and CD127 expression by NKp46+ cells indicating an increase in ILC3s. Our findings indicate that Lactobacillus feeding regulates the innate lymphoid cell population that may contribute to host defensive function during Salmonella infection.
topic Functional foods
Innate lymphoid cells
Lactobacilli
NKp46+ cells
Probiotics
Salmonella
url http://www.sciencedirect.com/science/article/pii/S1756464616000761
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