Anemia falciforme: desafios e avanços na busca de novos fármacos

Anemia falciforme: desafios e avanços na busca de novos fármacos

Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years...

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Main Authors: Jean Leandro dos Santos, Chung Man Chin
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
Sickle Cell Disease
drug discovery
molecular modification
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400025&lng=en&tlng=en
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spelling doaj-6b521f7d35114bdfbbc07dfa735057992020-11-25T01:07:47ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642012-01-0135478379010.1590/S0100-40422012000400025S0100-40422012000400025Anemia falciforme: desafios e avanços na busca de novos fármacosJean Leandro dos Santos0Chung Man Chin1Universidade Estadual PaulistaUniversidade Estadual PaulistaSickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400025&lng=en&tlng=enSickle Cell Diseasedrug discoverymolecular modification
collection DOAJ
language English
format Article
sources DOAJ
author Jean Leandro dos Santos
Chung Man Chin
spellingShingle Jean Leandro dos Santos
Chung Man Chin
Anemia falciforme: desafios e avanços na busca de novos fármacos
Química Nova
Sickle Cell Disease
drug discovery
molecular modification
author_facet Jean Leandro dos Santos
Chung Man Chin
author_sort Jean Leandro dos Santos
title Anemia falciforme: desafios e avanços na busca de novos fármacos
title_short Anemia falciforme: desafios e avanços na busca de novos fármacos
title_full Anemia falciforme: desafios e avanços na busca de novos fármacos
title_fullStr Anemia falciforme: desafios e avanços na busca de novos fármacos
title_full_unstemmed Anemia falciforme: desafios e avanços na busca de novos fármacos
title_sort anemia falciforme: desafios e avanços na busca de novos fármacos
publisher Sociedade Brasileira de Química
series Química Nova
issn 1678-7064
publishDate 2012-01-01
description Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.
topic Sickle Cell Disease
drug discovery
molecular modification
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400025&lng=en&tlng=en
work_keys_str_mv AT jeanleandrodossantos anemiafalciformedesafioseavancosnabuscadenovosfarmacos
AT chungmanchin anemiafalciformedesafioseavancosnabuscadenovosfarmacos
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