Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects

Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects

This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was...

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Main Authors: Koichi Miyaki, Htay Lwin, Katsunori Masaki, Yixuan Song, Yoshimitsu Takahashi, Masaaki Muramatsu, Takeo Nakayama
Format: Article
Language:English
Published: MDPI AG 2009-03-01
Series:International Journal of Environmental Research and Public Health
Subjects:
ALAD gene
blood lead level
environmentally lead exposure
Japanese
Online Access:http://www.mdpi.com/1660-4601/6/3/999/
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spelling doaj-6b4a3b5256d24b18a49e7d8cdaccf0a82020-11-25T00:49:59ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012009-03-0163999100910.3390/ijerph6030999Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese SubjectsKoichi MiyakiHtay LwinKatsunori MasakiYixuan SongYoshimitsu TakahashiMasaaki MuramatsuTakeo NakayamaThis cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed. http://www.mdpi.com/1660-4601/6/3/999/ALAD geneblood lead levelenvironmentally lead exposureJapanese
collection DOAJ
language English
format Article
sources DOAJ
author Koichi Miyaki
Htay Lwin
Katsunori Masaki
Yixuan Song
Yoshimitsu Takahashi
Masaaki Muramatsu
Takeo Nakayama
spellingShingle Koichi Miyaki
Htay Lwin
Katsunori Masaki
Yixuan Song
Yoshimitsu Takahashi
Masaaki Muramatsu
Takeo Nakayama
Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
International Journal of Environmental Research and Public Health
ALAD gene
blood lead level
environmentally lead exposure
Japanese
author_facet Koichi Miyaki
Htay Lwin
Katsunori Masaki
Yixuan Song
Yoshimitsu Takahashi
Masaaki Muramatsu
Takeo Nakayama
author_sort Koichi Miyaki
title Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_short Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_full Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_fullStr Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_full_unstemmed Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects
title_sort association between a polymorphism of aminolevulinate dehydrogenase (alad) gene and blood lead levels in japanese subjects
publisher MDPI AG
series International Journal of Environmental Research and Public Health
issn 1660-4601
publishDate 2009-03-01
description This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.
topic ALAD gene
blood lead level
environmentally lead exposure
Japanese
url http://www.mdpi.com/1660-4601/6/3/999/
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