TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes

TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes

Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky cargo collagen? TANGO1 is known to form a ring that corrals COPII coats, and we...

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Bibliographic Details
Main Authors: Ishier Raote, Maria Ortega-Bellido, António JM Santos, Ombretta Foresti, Chong Zhang, Maria F Garcia-Parajo, Felix Campelo, Vivek Malhotra
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
extracellular matrix
secretion
Multisubunit Tether Complex
STED
lineactant
Online Access:https://elifesciences.org/articles/32723

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